Cobalt(II) chloride (CAS 7646-79-9)

Cobalt(II) chloride (CoCl₂) is the most common cobalt compound found in laboratories. The dramatic color change of blue-purple Cobalt(II) chloride to a rose color when hydrated makes CoCl₂ an excellent indicator for water in dessicants. As an inducer of HIF-1 production, Cobalt(II) chloride has been used to study apoptotic effects in HepG2 cells. Also reported as a stabilizer for reconstitution of the radiopharmaceutical technetium-99m exametazime. CoCl₂ has been used in studies to examine heat shock protein expression of inflamed skin.
Also available: Cobalt(II) chloride hexahydrate (sc-203004).

References:

1. Expression of heat shock proteins in heavy metal-provoked inflamed human skin.  |  Nordlind, K. 2002. Immunopharmacol Immunotoxicol. 24: 383-94. PMID: 12375735
2. CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.  |  Piret, JP., et al. 2002. Ann N Y Acad Sci. 973: 443-7. PMID: 12485908
3. Chromosomal aberrations induced by cobaltous chloride in mice in vivo.  |  Palit, S., et al. 1991. Biol Trace Elem Res. 29: 139-45. PMID: 1713470
4. Cobalt (II) chloride promoted formation of honeycomb patterned cellulose acetate films.  |  Naboka, O., et al. 2012. J Colloid Interface Sci. 367: 485-93. PMID: 22074692
5. Bis[bis-(penta-methyl-cyclo-penta-dien-yl)cobalt(III)] tetra-chlorido-cobaltate(II) di-chloro-methane disolvate.  |  Merola, JS., et al. 2013. Acta Crystallogr Sect E Struct Rep Online. 69: m504. PMID: 24426998
6. A redox-silent analogue of tocotrienol inhibits cobalt(II) chloride-induced VEGF expression via Yes signaling in mesothelioma cells.  |  Sato, A., et al. 2014. Biol Pharm Bull. 37: 865-70. PMID: 24790010
7. Lutein Attenuates Both Apoptosis and Autophagy upon Cobalt (II) Chloride-Induced Hypoxia in Rat Műller Cells.  |  Fung, FK., et al. 2016. PLoS One. 11: e0167828. PMID: 27936094
8. Cobalt(II) chloride adducts with acetonitrile, propan-2-ol and tetrahydrofuran: considerations on nuclearity, reactivity and synthetic applications.  |  Stinghen, D., et al. 2017. Acta Crystallogr C Struct Chem. 73: 104-114. PMID: 28157128
9. Cobalt(II) Chloride Modifies the Phenotype of Macrophage Activation.  |  Kumanto, M., et al. 2017. Basic Clin Pharmacol Toxicol. 121: 98-105. PMID: 28244246
10. Crystal structure of hexa-kis-(dimethyl sulfoxide- kappa O)cobalt(II) bis-[tri-chlorido-(quinoline- kappa N)cobaltate(II)].  |  Brescia, TK., et al. 2018. Acta Crystallogr E Crystallogr Commun. 74: 309-312. PMID: 29765712
11. Triterpenoid corosolic acid attenuates HIF-1 stabilization upon cobalt (II) chloride-induced hypoxia in A549 human lung epithelial cancer cells.  |  Bahadori, MB., et al. 2019. Fitoterapia. 134: 493-500. PMID: 30898728
12. The Effects of Inactivation of Pedunculopontine Tegmental Nucleus by Cobalt (II) Chloride on Cardiovascular Responses in Hemorrhagic Hypotensive Rats.  |  Mohebbati, R., et al. 2019. Basic Clin Neurosci. 10: 235-244. PMID: 31462978
13. Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery.  |  Marinković, M., et al. 2021. Autophagy. 17: 1232-1243. PMID: 32286918
14. Cobalt (II) Chloride Regulates the Invasion and Survival of Brucella abortus 544 in RAW 264.7 Cells and B6 Mice.  |  Huy, TXN., et al. 2022. Pathogens. 11: PMID: 35631117
15. Evaluation of technetium-99m exametazime stabilised with cobalt chloride as a blood flow tracer in focal cerebral ischaemia.  |  Gartshore, G., et al. 1994. Eur J Nucl Med. 21: 913-23. PMID: 7995284